Scott's syndrome

Abstract

The coagulation of blood involves a sequential process in which multiple blood factors interact, ultimately resulting in the formation of an insoluble fibrin clot. This process can be divided into three stages. Stage 1 is the formation of intrinsic and extrinsic prothrombin converting principle, Stage 2 is the formation of thrombin, and Stage 3 is the formation of stable fibrin polymers. Scott’s syndrome is characterized by a faulty or absent scramblase (a carrier-like protein that takes the enzyme necessary for coagulation from the inside of the cell membrane to the outside), such that cells cannot send phosphatidylserine (PS) from their inner plasma membrane to their outer plasma membrane, which signals coagulation to begin. This condition had never been reported in horses (until recently), but has been known to occur in humans and dogs.