Abstract
Recent neurochemical results suggest the hypothesis that the nucleus basalis magnocellularis (nbm) cholinergic projection to the amygdala may play a role in memory. The present study investigated the effects of intraamygdaloid injections of the cholinergic antagonist Scopolamine on working and reference memory in the double Y-maze. Rats were pretrained until working and reference memory choice accuracy stabilized to a criterion of ≥86% correct. Bilateral cannulae were then surgically implanted in the basolateral amygdaloid complex. Rats ( n = 9) received Scopolamine in doses of 8.0, 24.0, and 72.0 μ//0.5 μl and saline (0.5 μl) in a counterbalanced order with retraining to criterion between injections. Intraamygdaloid scopolamine produced a dose-dependent and differential impairment of working and reference memory. A dose of 24.0 μg impaired working memory without significantly affecting reference memory; doses of 8.0 μg and 72.0 μg affected neither and both types of memory, respectively. Results implicate amygdaloid acetylcholine in memory.
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