Scope of application of the ursodeoxycholic acid at gastroenterological pathology

Abstract

The article presents modern concepts on the using of ursodeoxycholic acid in the clinical practice of internist. The presented review is focused on the effects of ursodeoxycholic acid, the current spectrum of it’s application in the treatment of the patients with gastroenterological pathology, in particular, gastroesophageal reflux disease, non-alcoholic fatty liver disease, autoimmune hepatobiliary processes, chronic hepatitis, intestinal dysbiosis. The literature review has covered the historical data on the release of ursodeoxycholic acid, the first studies on the results of this drug using, and listed the ursodeoxycholic acid effects and scope of application. The literature review presents data from the global studies of the ursodeoxychloric acid effects on patients with the above listed nosology. The efficacy of its preparation has been proved in terms of reduction of the clinical manifestations of intrahepatic cholestasis in pregnant women without side effects. The presented data showed the survival prolongation in patients with primary biliary cholangitis against the background of ursodeoxychloric acid administration. It has been emphasized that long-term use of ursodeoxycholic acid at viral hepatitis, along with etiotropic therapy, allowed to eliminate the clinical manifestations and to avoid the development of complications. It was demonstrated that ursodeoxycholic acid has protective properties against the damaging effect of bile acids on the esophagus walls at gastroesophageal reflux disease. The data have been presented on the UCDA positive effects on the lipid spectrum in patients with non-alcoholic fatty liver disease. The data illustrating the significant positive differences in the composition and function of the microbiome after prolonged use of ursodeoxycholic acid have been outlined.