Scoliotic disease: report to the teacher

A M Zaidman

doi:10.14531/ss2020.3.117-133

Abstract

It is with gratitude that I dedicate my work to the teacher, Ya.L. Tsivyan, who not only provided a subject for research, but also, on his own example of a person devoted to his work, brought up a generation of scholars for whom life and science are inseparable.The paper presents the results of many years of research on idiopathic scoliosis in the form of a report to the teacher. Several fundamental topics were considered:1) for the first time in world practice, it was established, on the basis of a study of 50 patients with idiopathic scoliosis, that the etiological factor of scoliosis is ectopic localization of neural crest derivatives, which are not genetically determined to chondrogenic differentiation and the growth process, in the vertebral body growth plate;2) a local disturbance of chondrogenesis in the vertebral body growth plate is the cause of the growth asymmetry and formation of spinal deformity in idiopathic scoliosis;3) the degree of structural changes in the spine and the prognosis of the deformity progression depend on the level of disturbance of the morphogenetic processes in the vertebral body growth plate embedded in embryogenesis;4) it is supposed to confirm the proposed hypotheses by inhibition of thePAX3gene in the chick embryo model of idiopathic scoliosis and to get answers to many more unclear questions concerning scoliotic disease.

Highlights

С благодарностью посвящаю свой труд учителю – Я.Л
It is with gratitude that I dedicate my work to the teacher, Ya.L
Tsivyan, who provided a subject for research, and, on his own example of a person devoted to his work, brought up a generation of scholars for whom life and science are inseparable

Summary

Introduction

С благодарностью посвящаю свой труд учителю – Я.Л. Цивьяну, который не только предоставил тему для исследования, но и на своем примере человека, преданного делу, воспитал поколение учеников, жизнь и наука для которых неотделимы. Относительный уровень экспрессии генов, регулирующих процесс хондрогенной дифференцировки, в хондробластах пластинок роста тел позвонков больных идиопатическим сколиозом и хондробластах позвоночника эмбриона: синие столбики – выпуклая сторона деформации, голубые столбики – вогнутая сторона деформации, белые столбики – контроль (позвоночник эмбриона).

Results

Conclusion