SCN2B, a possible crucial molecule involved in the aging associated Alzheimer's disease

Abstract

Alzheimer's disease (AD) is associated with a variety of pathophysiological features, including amyloid plaques, beta‐amyloid‐containing plaques, neurofibrillary tangles, and degeneration of cholinergic neurons, synaptic and neuronal loss in the brain, inflammation, immunological changes, cell death, and regeneration processes, altered neurotransmission, and age‐related changes. Sodium channel voltage‐gated beta 2 (SCN2B) is relevant to all of these. Here we reviewed the pathology, pharmacology, and biochemistry of AD in relation to SCN2B, and we suggest that SCN2B are candidate molecules for the treatment of AD.