Abstract

The specific aims of the study were to compare possible differences in sclerostin and preadipocyte factor-1 (Pref-1) between rhythmic gymnasts (RG), swimmers (SW) and untrained controls (UC), and to investigate the relationships of sclerostin and Pref-1 with bone mineral characteristics in studied groups. This study included 62 eumenorrheic adolescents (RG = 22; SW = 20; UC = 20). Bone mineral and body composition characteristics were measured by dual-energy X-ray absorptiometry, and sclerostin, Pref-1, osteocalcin and C-terminal telopeptide of type I collagen (CTx) were measured. Sclerostin was higher (P = 0.001) in RG (129.35 ± 51.01pg/ml; by 74%) and SW (118.05 ± 40.05pg/ml; by 59%) in comparison with UC (74.32 ± 45.41pg/ml), while no differences (P = 0.896) were seen in Pref-1 (RG: 1.42 ± 0.16ng/ml; SW: 1.41 ± 0.20ng/ml; UC: 1.39 ± 0.26ng/ml) between groups. Osteocalcin (RG: 7.74 ± 4.09ng/ml; SW: 8.05 ± 4.18ng/ml; UC: 7.04 ± 3.92ng/ml; P = 0.843) and CTx (RG: 0.73 ± 0.22ng/ml; SW: 0.64 ± 0.16ng/ml; UC: 0.62 ± 0.20ng/ml; P = 0.173) were not different between groups. Sclerostin correlated (P < 0.05) with whole-body bone mineral content (r = 0.61) and lumbar spine (LS) areal bone mineral density (aBMD) (r = 0.43) in RG, and femoral neck aBMD (r = 0.45) in UC. No correlation was found between sclerostin and bone mineral values in SW, and Pref-1 was not correlated with any bone mineral characteristics in studied groups. Sclerostin was the independent variable that explained 14% of the total variance (R2 × 100) in LS aBMD value only in RG. Adolescent athletes have higher sclerostin compared to UC. Sclerostin was correlated with bone mineral values and predicted areal bone mineral density in RG.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.