Abstract
species, and improved metabolic stability. Long term (21 months) treatment of ovx’d rhesus monkeys with ODN resulted in full protection of bone mineral density (BMD) loss at the spine and the hip, and maintenance of bone quality. Interestingly, ODN increases periosteal bone formation rate in the proximal femoral shaft and at the femoral neck. In clinical trials, ODN at 50 mg/week taken orally for three years increased lumbar spine and hip BMD in postmenopausal women with low bone mass. These results suggest that inhibition of Cat K may offer a novel therapeutic approach for treatment of post-menopausal osteoporosis.
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