Abstract
Sclerosing angiomatoid nodular transformation of the splenic red pulp has been described quite recently; many of the lesions previously diagnosed as splenic exuberant granulation tissue, multinodular hemangioma, and inflammatory pseudotumor could actually belong to this category. The lesion has been well reported intermittently in the past, but new cases with still newer associations keep appearing from time to time. There are no known risk factors and no inciting triggers have been proven. We report two such cases- one of which has extensive extramedullary haematopoiesis; a feature that has never been reported earlier. Clinico-morphological and radiological features along with pathogenesis are discussed in detail.
Highlights
One of our cases was associated with extensive extra-medullary haematopoiesis in the spleen - a finding that has never been reported in literature
Vascular neoplasms in spleen are common and may exhibit a variety of biological behaviour. These include those with a benign course and those that are frankly malignant [1]
The characteristic morphology of multiple angiomatoid nodules forming a space-occupying lesion in spleen is currently called as sclerosing angiomatoid nodular transformation (SANT)
Summary
A distinct subset of these tumors with characteristic morphology and typical immunoprofile has been designated as “Sclerosing Angiomatoid Nodular Transformation” (SANT). We describe two cases of SANT with characteristic histomorphology and immunoprofile. One of our cases was associated with extensive extra-medullary haematopoiesis in the spleen - a finding that has never been reported in literature
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