Abstract
Systemic sclerosis is an autoimmune connective tissue disorder characterized by endothelial cell injury, vascular hyper-reactivity, obliterative microvasculopathy and excess collagen deposition, particularly within the dermis of the skin. Table 1 outlines the various terms that are used to describe the extent and location of sclerosis. Limited cutaneous and diffuse cutaneous are the two main forms that exist.
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