Abstract
Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death (SCD) in young adults ≤ 40 years of age. Myocardial fibrosis is a well-known histological marker of the disease. Numerous studies have assessed this parameter using cardiac magnetic resonance (CMR) and serum biomarkers of extracellular matrix (ECM) including collagen and matrix metalloproteinases. Although ECM biomarkers are overexpressed in HCM patients with left ventricular tract obstruction and myocardial fibrosis, they do not strongly correlate with an increased risk of SCD.
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