Abstract
Abstract The gastro-intestinal transit of a sustained release theophylline tablet labelled with a gamma-emitting radionuclide has been studied in human subjects. Gastric emptying was monitored using a gamma camera. Fasting conditions have been previously described, characterised by a 72±25 min (mean±S.D.) gastro-duodenal transit time. In the same volunteers, after a high fat breakfast, the tablets entered into the duodenum 258±75 min (mean±S.D.) after intake. However, the amounts of theophylline absorbed were similar between the two treatments, assuming that, in spite of the transit time increase, theophylline release is not affected by simultaneous intake of a heavy meal.
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