Abstract
Diagnosis by serial bone scan was performed on 134 patients with bone tumours using the radioactive isotopes 99m TcEHDP, 99m TcBleo and 67 Ga. 99m TcEHDP bone scan was found to be a highly sensitive screening test in patients with skeletal metastases from malignant bone tumours. Malignant bone tumours demonstrated a marked uptake of all three radiopharmaceuticals. Benign bone tumours did not reveal any abnormal accumulation. The exceptions however were myeloma which showed a decreased uptake in the lesion compared to the background radioactivity and also giant cell tumours which showed an abnormal uptake of all three bone-seeking radiopharmaceuticals. Bone scanning using 99m TcEHDP combined with 99m TcBleo and 67 Ga is a safe, simple and sensitive method for the detection and evaluation of bone tumours. It should, however, be emphasised that there are several pitfalls in the interpretation of bone scans. These include fractures in benign bone tumours and chronic osteomyelitis.
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