Scientometric analysis of evidence-based studies of physical methods of post-acne scar correction

Abstract

Scientometric analysis of evidence-based studies on the use of therapeutic physical factors in the correction of post-acne scars. The analysis of evidence-based studies in electronic databases (PEDro, PubMed, eLibrary) and in databases of systematic reviews (Cochrane database) for the period from 2015 to 2020 was carried out. The following terms in Russian and English were taken as key words: acne scars (acne scarring), physical therapy (physical therapy). The final assessment of physical methods of correction included mainly data from foreign systematic reviews, meta-analyzes of RCTs, data from individual RCTs in English and/or Russian and tests rated at 4 points or higher on the PEDro scale. The clinical effects and supposed mechanisms of action of the currently proven therapeutic physical factors in the treatment of patients with post-acne scars are considered in detail. The most studied physical methods are technologies of high-intensity laser therapy (44.2%), fractional radiofrequency therapy (17%), combined methods of exposure (high-intensity laser therapy or micro-needling in combination with peels, fillers, PRP injection) (25%), micro-needling as monotherapy (5.8%) and microdermabrasion (4.5%) causing the most significant clinical changes and pronounced remodeling of the extracellular matrix of the skin in the area of scars. There is a need for regular synthesis and analysis of existing evidence-based studies, as well as the implementation of new high-quality randomized controlled clinical trials to study the effect of physical correction methods on post-acne scars which serve as the basis for the development of clinical guidelines.