Abstract
With a simple package in the mail, scientists can start studying how their favorite protein interacts with millions of small molecules. This is what researchers from the Novartis Institutes for Biomedical Research and the Broad Institute of MIT and Harvard said they hope will happen as they announced their new open-source DNA-encoded library (DEL) at the American Chemical Society national meeting in San Diego last week. DELs are large pools of small molecules, each attached to a ribbon of DNA with a unique sequence of base pairs. Researchers can look for molecules in the DEL that bind to the protein, sequence the DNA tags to find the binding molecules’ identities, and then synthesize them for future studies. The Novartis-Broad DEL is different from other open-source DELs because of the 3 million compounds it contains—many have unusual structures and well-defined stereochemistries, said Liam Hudson, a postdoc at Novartis and Broad. Many
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