Abstract
AimsThe present study was aimed to study the in vitro antioxidant property by DPPH, superoxide, and hydroxyl radical scavenging assays, in vivo hepatoprotective activity by CCl4 induced hepatotoxicity in albino rats, formulation of polyherbal hepatoprotective tablets containing equal quantities of methanolic extract of roots of Begonia laciniata Roxb., whole plant of Cuscuta epithymum (L.) L and whole plant of Dendrobium ovatum (L.) Kraenzl., which were used traditionally in Chittoor and Khammam districts of Andhra Pradesh, India. MethodsFormulation was developed by direct compression method using super tab-11SD, primojel, talc and magnesium stearate as excipients and then subjected to evaluation of precompression and post compression parameters. Results and conclusionAll the selected plants showed dose dependant antioxidant property, highest at 360 μg dose and significant dose dependant hepatoprotective activity, highest at a dose of 400 mg/kg b.w compared to standard drug silymarin, the histopathological studies also confirmed protective effects of extracts against CCl4-induced liver injuries. The observations from formulation support the ideal properties of compressed tablets and its feasibility for large-scale commercial production.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
