Scientific Opinion on the substantiation of health claims related to gamma linolenic acid and maintenance of joints (ID 494, 637, 1774, 2098), weight maintenance following weight loss (ID 496), maintenance of peripheral blood flow (ID 638), maintenance of normal blood pressure (ID 1771), maintenance of normal blood cholesterol concentrations (ID 1771) and maintenance of bone (ID 1774) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

Abstract

EFSA JournalVolume 8, Issue 2 1477 OpinionOpen Access Scientific Opinion on the substantiation of health claims related to gamma linolenic acid and maintenance of joints (ID 494, 637, 1774, 2098), weight maintenance following weight loss (ID 496), maintenance of peripheral blood flow (ID 638), maintenance of normal blood pressure (ID 1771), maintenance of normal blood cholesterol concentrations (ID 1771) and maintenance of bone (ID 1774) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)Search for more papers by this author EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)Search for more papers by this author First published: 25 February 2010 https://doi.org/10.2903/j.efsa.2010.1477Citations: 13 Panel members: Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Hannu Korhonen, Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley, Monika Neuhäuser-Berthold, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Stephan Strobel, Inge Tetens, Daniel Tomé, Hendrik van Loveren and Hans Verhagen. Correspondence: nda@efsa.europa.eu Acknowledgement: The Panel wishes to thank for the preparation of this opinion: The members of the Working Group on Claims : Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Marina Heinonen, Hannu Korhonen, Martinus Løvik, Ambroise Martin, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Inge Tetens, Hendrik van Loveren and Hans Verhagen. The members of the Claims Sub-Working Group on Cardiovascular Health/Oxidative Stress: Antti Aro, Marianne Geleijnse, Marina Heinonen, Ambroise Martin, Wilhelm Stahl and Henk van den Berg. The members of the Claims Sub-Working Group on Bone/Teeth/Connective Tissue: Rikke Andersen, Olivier Bruyère, Albert Flynn, Ingegerd Johansson, Jukka Meurman and Hildegard Przyrembel. Adoption date: 21 December 2009 Published date: 25 February 2010 Question number: EFSA-Q-2008-1281, EFSA-Q-2008-1283, EFSA-Q-2008-1424, EFSA-Q-2008-1425, EFSA-Q-2008-2504, EFSA-Q-2008-2507, EFSA-Q-2008-2831 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Belch JJ, Shaw B, O'Dowd A, Saniabadi A, Leiberman P, Sturrock RD and Forbes CD, 1985. Evening primrose oil (Efamol) in the treatment of Raynaud's phenomenon: a double blind study. Journal of Thrombosis and Haemostasis, 54, 490– 494. Belch JJ, Ansell D, Madhok R, O'Dowd A and Sturrock RD, 1988. Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. Annals of the Rheumatic Diseases, 47, 96– 104. Belch JJ and Hill A, 2000. Evening primrose oil and borage oil in rheumatologic conditions. American Journal of Clinical Nutrition, 71 (1 Suppl), 352S– 356S. Brzeski M, Madhok R and Capell HA, 1991. Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. British Journal of Rheumatology, 30, 370– 372. Calder PC and Zurier RB, 2001. Polyunsaturated fatty acids and rheumatoid arthritis. Current Opinion in Clinical Nutrition and Metabolic Care, 4, 115– 121. Cameron NE and Cotter MA, 1999. Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes. Diabetes Research and Clinical Practice, 45, 137– 146. Chilton L, Surette ME, Swan DD, Fonteh AN, Johnson MM and Chilton FH, 1996. Metabolism of gamma-linolenic acid in human neutrophils. Journal of Immunology, 156, 2941– 2947. Coste T, Pierlovisi M, Leonardi J, Dufayet D, Gerbi A, Lafont H, Vague P and Raccah D, 1999. Beneficial effects of gamma linolenic acid supplementation on nerve conduction velocity, Na+, K+ ATPase activity, and membrane fatty acid composition in sciatic nerve of diabetic rats. Journal of Nutritional Biochemistry, 10, 411– 420. DeLuca P, Rossetti RG, Alavian C, Karim P and Zurier RB, 1999. Effects of gammalinolenic acid on interleukin-1ß, and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo. Journal of Investigative Medicine, 42, 246– 250. Dines KC, Cameron NE and Cotter MA, 1995. Comparison of the effects of evening primrose oil and triglycerides containing gamma-linolenic acid on nerve conduction and blood flow in diabetic rats. Journal of Pharmacology and Experimental Therapeutics, 273, 49– 55. Dines KC, Cotter MA and Cameron NE, 1996. Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. Prostaglandins Leukotrienes and Essential Fatty Acids, 55, 159– 165. Furse RK, Rossetti RG and Zurier RB, 2001. Gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, blocks amplification of IL-1 beta production by human monocytes. Journal of Immunology, 167, 490– 496. Hansen TM, Lerche A, Kassis V, Lorenzen I and Sondergaard J, 1983. Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. Scandinavian Journal of Rheumatology, 12, 85– 88. Head RJ, McLennan PL, Raederstorff D, Muggli R, Burnard SL and McMurchie EJ, 2000. Prevention of nerve conduction deficit in diabetic rats by polyunsaturated fatty acids. American Journal of Clinical Nutrition, 71 (1 Suppl), 386S– 392S. Jamal GA and Carmichael H, 1990. The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial. Diabetic Medicine, 7, 319– 323. Jäntti J, Seppala E, Vapaatalo H and Isomaki H, 1989. Evening primrose oil and olive oil in treatment of rheumatoid arthritis. Clinical Rheumatology, 8, 238– 244. Kast RE, 2001. Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha. International Immunopharmacology, 1, 2197– 2199. Keen H, Payan J, Allawi J, Walker J, Jamal GA, Weir AI, Henderson LM, Bissessar EA, Watkins PJ, Sampson M, et al., 1993. Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. Diabetes Care, 16, 8– 15. Leng GC, Lee AJ, Fowkes FG, Jepson RG, Lowe GD, Skinner ER and Mowat BF, 1998. Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease. Clinical Nutrition, 17, 265– 271. Leventhal LJ, Boyce EG and Zurier RB, 1993. Treatment of rheumatoid arthritis with gammalinolenic acid. Annals of Internal Medicine, 119, 867– 873. Leventhal LJ, Boyce EG and Zurier RB, 1994. Treatment of rheumatoid arthritis with blackcurrant seed oil. British Journal of Rheumatology, 33, 847– 852. No authors listed, 2004. Gamma-linolenic acid (GLA). Monograph. Alternative Medicine Review, 9, 70– 78. Pullman-Mooar S, Laposata M, Lem D, Holman RT, Leventhal LJ, Demarco D and Zurier RB, 1990. Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid. Arthritis and Rheumatism, 33, 1526– 1533. Rossetti RG, Seiler CM, DeLuca P, Laposata M and Zurier RB, 1997. Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. Journal of Leukocyte Biology, 62, 438– 443. Schirmer MA and Phinney SD, 2007. Gamma-linolenate reduces weight regain in formerly obese humans. Journal of Nutrition, 137, 1430– 1435. Vinik AI, Park TS, Stansberry KB and Pittenger GL, 2000. Diabetic neuropathies. Diabetologia, 43, 957– 973. Watson J, Byars ML, McGill P and Kelman AW, 1993. Cytokine and prostaglandin production by monocytes of volunteers and rheumatoid arthritis patients treated with dietary supplements of blackcurrant seed oil. British Journal of Rheumatology, 32, 1055– 1058. Wu D, Meydani M, Leka LS, Nightingale Z, Handelman GJ, Blumberg JB and Meydani SN, 1999. Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjects. American Journal of Clinical Nutrition, 70, 536– 543. Yaqoob P, Pala HS, Cortina-Borja M, Newsholme EA and Calder PC, 2000. Encapsulated fish oil enriched in α-tocopherol alters plasma phospholipids and mononuclear cell fatty acid compositions but not mononuclear cell functions. European Journal of Clinical Investigation, 30, 260– 274. Zurier RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM and Laposata M, 1996. Gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Arthritis and Rheumatism, 39, 1808– 1817. Citing Literature Volume8, Issue2February 20101477 ReferencesRelatedInformation