Schistosoma mansoni: IgG and IgE Skin-sensitizing antibodies in infected baboons

Abstract

Affinity chromatography absorption of serum from baboons infected with Schistosoma mansoni, using immunoadsorbents made with monospecific anti-human IgE and anti-baboon IgG, demonstrated that antibodies belonging to both these classes participate in the antigen-induced release of vasoactive mediators. Skin-sensitizing IgG was detected by passive cutaneous anaphylaxis in rhesus monkey skin after a latent period of 2 hr, while IgE was detected in 24-hr latent period PCA. Both types of reactivity were abolished by double absorption; both were recovered in the eluates from the respective immunoabsorbents, although with diminished potency.