Abstract
The immunological response of human beings, chimpanzees, rhesus and cercopithecus monkeys, rabbits, guinea pigs, and mice to infection with Schistosoma mansoni or S. haematobium was studied. Antibodies detected by fluorescent and flocculating techniques were heat stable, not sensitive to 2-mercaptoethanol, and were eluted from Sephadex G-200 in the IgG fraction. Antibodies detected by anaphylactic reactions were destroyed by heating, were inactivated by reduction and alkylation, had a faster electrophoretic mobility than IgG, and were eluted from Sephadex G-200 after IgM and before IgG. Differences in passive cutaneous anaphylactic (PCA) antibody reactions among animals of a given species could not be attributed to differences in worm burdens, organ involvement, or egg excretion. Conversely, the percentage of animals in each species producing PCA antibodies correlated directly with the degree of resistance to the various species studied as determined by the percentage of worm recovery, the general appearance of worm development, the pattern of egg excretion, and the clinical and pathological observations.
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