Schisandrins impact on the efficiency of human body: A review

Abstract

Summary News Schisandrins are a group of chemical components, contained in Schisandra chinensis, determined as lignans. They involve: schisandrin A, B, C and schisandrol A. Those substances, which are well-known in traditional Chinese medicine, are hepatoprotective, anti-inflammatory, antioxidative and antineoplastic. Furthermore, there is a wide array of trials and analyses performed on animal models, which makes us presume that after running trials on a human model, schisandrins will be used as sport supplements. Those components stimulate skeletal muscles hypertrophy; there is a proved impact on soleus and gastrocnemius muscles, as well as the protective and regenerative role. Lignans decrease triglycerides and total cholesterol levels, leading to body mass reduction. They are also hypoglycemic, facilitate the transport and metabolism of glucose as GLUT-2 activators or adiponectin antagonists. They enhance the sensitivity to insulin, lowering the levels of interleukin 1, interleukin 2 and interleukin 6. The components have also nephroprotective activity in hyperglycemic states, arresting the progression of the disorder. Schisandrins influence the endocrine system, decreasing cortisol level and slightly increasing testosterone level. Conclusion In our review we juxtapose the trials, emphasizing the schisandrins impact on the efficiency of human body. Effects of use of schisandrins are very promising, however, there is still not enough of good evidences to use these substances without any doubts. There are also reports of interactions with CYP3A4 or induction of hypertriglyceridemia.