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Abstract
Two novel phospholipase D (PLD) inhibitors, Sch 53823 ( 1) and Sch 53825 ( 2), were isolated from a fungal culture. The acetylated derivatives, Sch 53827 ( 3) and Sch 53829 ( 4), were prepared for the purpose of structure determination. The extensive NMR studies of 3 and 4 including DEPT, COSY, NOESY, HETCOR, and selective INEPT experiments permitted the establishment of their structures, as well as relative stereochemistries. Among these compounds, 3 exhibited the most potent inhibitory activity in the phospholipase D assay with the IC 50 = 17 μM.
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