Abstract
We studied the effects of peripheral and central administration of SCH 23390, a selective antagonist of dopamine D 1 receptors, on intracranial self-stimulation of the medial prefrontal cortex of the rat. Intraperitoneal injections of SCH 23390 produced a dose-related decrease in self-stimulation. Unilateral microinjections of SCH 23390 into the medial prefrontal cortex also produced a dose-related decrease in self-stimulation in the ipsilateral medial prefrontal cortex. However, self-stimulation of the contralateral, noninjected prefrontal cortex, used as control, was not affected. Together with previous data, the present results suggest that the dopamine neutotransmission involved in self-stimulation of the prefrontal cortex of the rat is mediated by dopamine D 1 receptors.
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