Scavenging Properties of Plant-Derived Natural Biomolecule Para-Coumaric Acid in the Prevention of Oxidative Stress-Induced Diseases.

Shubhadeep Roychoudhury,Barnali Sinha,Niraj Kumar Jha,Mokhtar Ibrahim Yousef,Adriana Kolesarova,Kavindra Kumar Kesari,Petr Slama,Surekha Kundu,Partha Palit,Subhash C Mandal,Janne Ruokolainen,Birupakshya Paul Choudhury

doi:10.3390/antiox10081205

Abstract

Para-coumaric acid (p-CA) is a plant derived secondary metabolite belonging to the phenolic compounds. It is widely distributed in the plant kingdom and found mainly in fruits, vegetables, and cereals. Various in vivo and in vitro studies have revealed its scavenging and antioxidative properties in the reduction of oxidative stress and inflammatory reactions. This evidence-based review focuses on the protective role of p-CA including its therapeutic potential. p-CA and its conjugates possesses various bioactivities such as antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, and anti-melanogenic properties. Due to its potent free radical scavenging activity, it can mitigate the ill effects of various diseases including arthritis, neurological disorders, and cardio-vascular diseases. Recent studies have revealed that p-CA can ameliorate the harmful effects associated with oxidative stress in the reproductive system, also by inhibiting enzymes linked with erectile function.

Highlights

Neuroprotective effects by reducing ischemia reperfusion (IR)-induced brain oxidative stress Para-coumaric acid (p-CA) reduced the neurotoxicity in cisplantin-induced animals through its antioxidant property
As a large number of drugs have been developed from phytochemicals either directly or indirectly, the knowledge of chemical structure and mechanisms of action of phytochemicals can be used further to develop p-CA based drugs for the management of several oxidative stress induced diseases [82]
Belonging to the HCA family of phytochemicals, p-CA is synthesized from the precursor tyrosine and phenylalanine through the shikimic acid pathway

Summary

Introduction

Plant secondary metabolites are chemical compounds synthesized through various pathways. Such compounds do not aid in plant growth and development they enhance the survival mechanism of plants in different environmental conditions [1]. They possess biological activities and form the parts of human and animal diets. They are predominantly found in fruits, vegetables, cereals, and several other organic food products

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