Abstract
Class A scavenger receptors (SR-A) mediate microglial interaction with fibrillar β-amyloid (fAβ). We report here that neonatal microglia from SR-A knockout mice (SR-A −/−) adhere to surface-bound fAβ, and produce reactive oxygen species (ROS) as efficiently as wildtype microglia; that both wildtype and SR-A −/− microglia express SR-BI; that antibodies against SR-BI do not affect adhesion or ROS production by wildtype microglia, but inhibit adhesion and ROS production of SR-A −/− microglia to immobilized fAβ by ∼40%. Adhesion to fAβ-coated surfaces, and uptake of fAβ by both wildtype and SR-A −/− microglia was almost completely inhibited by incubation with fucoidan. Thus SR-BI and SR-A mediate similar effector functions in neonatal microglia, which suggests that SR-BI plays as important a role as SR-A, and can maintain the wildtype phenotype in SR-A −/− microglia.
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