Scatter estimation and correction using time-of-flight and deconvolution in x-ray medical imaging.

Abstract

Objective Time-of-flight (TOF) scatter rejection requires a total timing jitter,
including the detector timing jitter and the X-ray source's pulses width, of 50 ps or less
to mitigate most of the effects of scattered photons in radiography and CT imaging.
However, since the total contribution of the source and detector to the timing jitter
can be retrieved during an acquisition with nothing between the source and detector,
it can be demonstrated that this contribution may be partially removed to improve
the image quality.
Approach A scatter correction method using iterative deconvolution of the measured
time point-spread function estimates the number of scattered photons detected in each
pixel. To evaluate the quality of the estimation, GATE was used to simulate the
radiography of a water cylinder with bone inserts, and a head and torso in a system
with total timing jitters from 100 ps up to 500 ps full-width-at-half-maximum.
Main results With a total timing jitter of 200 ps, 89% of the contrast degradation
caused by scattered photons was recovered in a head and torso radiography, compared
to 28% with a simple time threshold method. Corrected images using the estimation
have a percent root-mean square error between 2 and 14% in both phantoms with
timing jitters from 100 to 500 ps which is lower than the error achieved with scatter
rejection alone at 100 ps.
Significance TOF X-ray imaging has the potential to mitigate the effects of the
scattering contribution and offers an alternative to anti-scatter grids that avoids loss
of primary photons. Compare to simple TOF scatter rejection using only a threshold,
the deconvolution estimation approach has lower requirements on both the source and
detector. These requirements are now within reach of state-of-the-art systems.