Abstract
In a study of the reaction of children to Dr. Larsen's ricinoleated scarlet fever antigen, as determined by the Dick test, a wide diversity of response has been noted. Frequently children with positive Dick tests developed negative skin reactions, sometimes as early as 4 days, following the administration of antigen, but a return to the original state of skin sensitivity was observed in the majority in 6 to 8 weeks. Only a very few remained negative for as long as 6 months.The variation in response is partially indicated by the following cases:Following antigen administration a decrease in reaction was noted in almost all who originally showed a markedly positive test. In a small number of cases 2 doses of antigen or even 3 failed to produce a negative test, or at least one which persisted over periods varying from 3 weeks to 3 months. An increase in reaction was noted frequently after the giving of antigen, which as a rule tended later to decrease, but in individuals who were originally slightly sensitiv...
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