Abstract
High resolution (sub nm) and direct height information obtained through scanning probe microscopy (SPM) (such as from the STM and AFM) establishes SPM as a valuable tool for the investigation of biological samples. Unfortunately SPM allows only regions of a few μm to be scanned at high speed. For biological applications this is a disadvantage, because most samples will be only of the μm size and scattered across the much larger substrate. To make SPM investigation of biological samples less tedious, we combined a STM (or alternatively an AFM) with an inverted confocal scanning laser microscope (CSLM), with a lateral and axial resolution of 200 nm and 400 nm, respectively. This enables to locate areas of interest on the substrate and position the tip of the STM. STM tips used are electro-chemically etched from Au to routinely attain tip radii in the 5 nm range. Catalase platelets were chosen as a sample, because of their established two different lattice repeats (17.5 nm and 6.8 nm).
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