Abstract
ABSTRACTBy using scanning electron microscopy (SEM), three dimensional structures of the matrixes and fibrous components in human dermal skin, scleromyxedema, systemic lupus erythematodes (SLE), progresive systemic sclerosis (PSS) and amyloidosis cutis were observed. SEM pictures were compared with those from conventional transmission electron microscopy and histochemistry. In human dermal skin and scleromyxedema, the matrixes were not fixed in glutaraldehyde and osmic acid. FAC fixation was employed in these specimens. After fixing specimens, streptomyces hyaluronidase digestion was made and examined by the SEM. In human dermis and scleromyxedema, hyarulonic acid occurred between collagen and elastic fibers.In systemic lupus erythematodes and progresive systemic sclerosis, specimens were fixed in glutaraldehyde and osmic acid, and examined in the same way. In SLE, collagen fibers were dissociated and the normal wavy pattern was lost. In PSS, abnormally increased branching fibers were observed. In amyloidosis cutis, amyloid fibrils were not observed by conventional SEM. Specimens were dehydrated in a critical point dryer and examined by the field emission scanning microscope. Amyloid fibrils were interwoven in a felt‐like fashion.
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