Abstract
α-Pyridyl tertiary amino acids have potential pharmaceutical applications because of their structural features. However, their synthesis is still highly limited. Herein, we report a straightforward approach for the electrochemical synthesis of tertiary α-substituted amino acid derivatives via three-component reductive coupling. Using gaseous ammonia as both the N and H source, the α-keto ester reacts directly with 4-CN-pyridine. The application of scandium catalysis is the key for achieving chemoselectivity among various side reaction pathways.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
