Abstract
The secretory carrier-associated membrane proteins (SCAMPs) are associated with the development of multiple human cancers. The role of SCAMPs in acute myeloid leukemia (AML), however, remains to be identified. In the present study, we explored expression patterns and prognostic value of SCAMPs and network analysis of SCAMPs-related signaling pathways in AML using Oncomine, GEPIA, cBioPortal, LinkedOmics, DAVID and Metascape databases. Genetic alteration analysis revealed that the mutation rate of SCAMP genes was below 1% (9/1272) in AML, and there was no significant correlation between SCAMPs gene mutation and AML prognosis. However, the SCAMP2/5 mRNA levels were significantly higher in AML patients than in healthy controls. Moreover, high mRNA expressions of SCAMP2/4/5 were associated with poor overall survival, which might be due to that SCAMP2/4/5 and their co-expressed genes were associated with multiple pathways related to tumorigenesis and progression, including human T-cell leukemia virus 1 infection, acute myeloid leukemia, mTOR and NF-kappa B signaling pathways. These results suggest that SCAMP2/4/5 are potential prognostic markers for AML, and that SCAMP2 and SCAMP5 individually or in combination may be used as diagnostic markers for AML.
Highlights
The secretory carrier-associated membrane proteins (SCAMPs) are associated with the development of multiple human cancers
SCAMP genetic changes were evident in 9 samples from 1162 acute myeloid leukemia (AML) patients; that is to say, the total alteration rate is below 1%
We collected several sets of data from multiple databases including Oncomine, GEPIA, cBioPortal, LinkedOmics and DAVID, and performed comprehensive bioinformatic analysis to evaluate the role of SCAMPs in AML
Summary
The secretory carrier-associated membrane proteins (SCAMPs) are associated with the development of multiple human cancers. High mRNA expressions of SCAMP2/4/5 were associated with poor overall survival, which might be due to that SCAMP2/4/5 and their co-expressed genes were associated with multiple pathways related to tumorigenesis and progression, including human T-cell leukemia virus 1 infection, acute myeloid leukemia, mTOR and NF-kappa B signaling pathways. These results suggest that SCAMP2/4/5 are potential prognostic markers for AML, and that SCAMP2 and SCAMP5 individually or in combination may be used as diagnostic markers for AML. We comprehensively analyzed the relationships between the five SCAMPs and AML based on the data from Oncomine, GEPIA (Gene Expression Profiling Interactive Analysis), cBioPortal, LinkedOmics and DAVID (the Database for Annotation, Visualization and Integrated Discovery), as a means of assessing SCAMP expression patterns, potential functions, and prognostic utility in the context of AML
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