Abstract
Exosomes are extracellular vesicles (EVs), that are secreted by different cells of the body and are considered as important players in cell-to-cell communication. Exosomes, and more specifically stem cell-derived exosomes are currently of great interest as cell-free therapeutic tools due to their strong diagnostic and therapeutical potential in various diseases models. To explore their use in various biomedical frameworks, large amounts of high-quality exosomes need to be produced. To meet this challenge, cell culture in the controlled environment offered by stirred-tank bioreactor can facilitate the standardized expansion of large numbers of viable cells and enhance the reproducible production of extracellular vesicles. In this article, we discuss the challenges of exosome production and provide insights in its scale-up in stirred-tank bioreactors.
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