Abstract
Wet granulation is studied in different granulators: conventional planetary mixers (Collette® and Ours®), high speed granulators (Moritz® TS10 and TS50) and Lödige® mixer. Apart from the type and size of apparatus, the quantity of granulating liquid and the kneading time vary according to experimental designs. A great number of variables are measured before, during and after compression of the produced granules. Results are collected and treated using the Response Surface Methodology. Comparison of the obtained response surfaces and superimposing the contourlines lead to a best knowledge of the scaling-up operation. A Multifactorial Analysis, more global but complement of the previous method, is performed in order to reveal the main differences as well as common properties between the different granulators, allowing so a general interpretation of their characteristics.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
