Abstract
The linear and nonlinear viscoelastic response of networks of cross-linked and bundled cytoskeletal filaments demonstrates remarkable scaling with both frequency and applied prestress, which helps elucidate the origins of the viscoelasticity. The frequency dependence of the shear modulus reflects the underlying single-filament relaxation dynamics for 0.1-10 rad/sec. Moreover, the nonlinear strain stiffening of such networks exhibits a universal form as a function of prestress; this is quantitatively explained by the full force-extension relation of single semiflexible filaments.
Highlights
The nonlinear strain stiffening of such networks exhibits a universal form as a function of prestress; this is quantitatively explained by the full force-extension relation of single semiflexible filaments
In this Letter, we demonstrate that the macroscopic mechanical response of F-actin networks can be explained quantitatively in terms of single-filament elasticity and dynamics, over a large range of filament and cross-linker concentrations
We show that the linear viscoelasticity of cross-linked networks of F actin can be scaled onto a single master curve as a function of frequency, despite orders of magnitude variation in the elastic moduli. This scaling reveals that the relaxation dynamics of single filaments is the dominant mechanism of dissipation in these cross-linked networks, even at low frequencies
Summary
Scaling of F-Actin Network Rheology to Probe Single Filament Elasticity and Dynamics The linear and nonlinear viscoelastic response of networks of cross-linked and bundled cytoskeletal filaments demonstrates remarkable scaling with both frequency and applied prestress, which helps elucidate the origins of the viscoelasticity. The elasticity of entangled solutions of actin filaments, in the absence of cross-links, is entropic in origin [3,4].
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