Abstract
The authors study the multi-scale aggregation and interface dynamics in cancer-endothelial cell mixtures, and demonstrate the correlated scale-free fluctuations of the structure and the velocity of cancer cluster boundaries.
Highlights
Fluctuating interfaces ubiquitously occur in various nonequilibrium media [1]
The cell system is a coupled active system exhibiting motions over a wide range of scales, which are important in many biological processes such as embryogenesis [18], tumorigenesis [19], and cancer metastasis [20,21,22]
We demonstrate the gradual aggregation of individual Cancer cells (CCs) and small CC clusters into larger
Summary
Fluctuating interfaces ubiquitously occur in various nonequilibrium media [1]. The interplay of different coherences generated by different mutual couplings on the two sides of the interface, and the disorder generated by passive/active forces, stochastic agitations, or mass inputs, could generate self-similar multiscale spatiotemporal interface fluctuations [1]. The multiscale structural and dynamical behaviors of aggregation and fluctuating cluster boundaries, and their correlation with turbulentlike cell motions of the proliferating monolayer binary cell mixture, from the dilute state with similar number fractions of the two types of cells with different motilities, remain unexplored.
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