Abstract
Abstract : A new scalaran class sesterterpenoid with five known ones was isolated from a marine sponge Smenospongia species collected from the Gageo island, Korea. Chemical structure of all of compounds was determined on the basis of a combination of extensive 1D and 2D NMR experiments and MS data. The new compound exhibited a new functional group on a common scalaran sesterterpene skeleton, identified as 12-deacetoxy-23-deacetoxyscalarin. The compound 1 moderately showed the effect of the activation of AMP-activated protein kinase (AMPK) in L6 myoblast cell. Keywords: 1D and 2D NMR, 12-deacetoxy-23-deacetoxyscalarin, sponge Smenospongia sp . , AMP-activated protein kinase (AMPK) INTRODUCTION Scalaran sesterterpenes are one of the most frequently encountered metabolites in sponges of the order Dictyoceratides. Moreover, these compounds showed a wide range of biological activities including cytotoxic, antimicrobial, antifeedant, platelet-aggregation inhibitory, and anti-inflammatory properties.
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