Abstract
The genus Scabiosa (family Caprifoliaceae) is considered large (618 scientific plant names of species) although only 62 have accepted Latin binominal names. The majority of the Scabiosa species are widely distributed in the Mediterranean region and some Scabiosa species are used in traditional medicine systems. For instance, Scabiosa columbaria L. is used traditionally against diphtheria while S. comosa Fisch. Ex Roem. and Schult. is used in Mongolian and Tibetan traditional medical settings to treat liver diseases. The richness of Scabiosa species in secondary metabolites such as iridoids, flavonoids and pentacyclic triterpenoids may contribute to its use in folk medicine. Details on the most recent and relevant pharmacological in vivo studies on the bioactive secondary metabolites isolated from Scabiosa species will be summarized and thoroughly discussed.
Highlights
From the pharmacological perspective, plants are a treasure
At the end of this survey, it is possible to recognize the richness of Scabiosa genus in bioactive secondary metabolites
From the secondary metabolites found in Scabiosa species these are the most evaluated ones
Summary
Plants are a treasure. the plant itself or its secondary metabolites are the source of useful drugs. Herbal remedies are enjoying a revival in developed countries, and in many countries, traditional medicine is the first option, or the only one, for health maintenance and disease prevention or treatment. In this context, Scabiosa species are significant due their applications in traditional medicine systems and due to their richness in bioactive compounds. Scabiosa species are annual plants with basal leaf rosettes and leafy stems They are mostly shrubs with variation in size from 10 cm, such as in Scabiosa stellata L. case [7], to 60 cm, in the case of Scabiosa atropurpurea L. We report and discuss the information on traditional medicine applications, bioactive natural compounds isolated from Scabiosa species, highlighting the more relevant metabolites and/or bioactivities
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