Abstract
6057 Background: We developed a Markov model to simulate outcomes in different sub-groups of patients with stage I NSCLC to help define the role of SBRT in this disease. Methods: We modeled the 5 year clinical history of (i) operable stage I NSCLC patients treated with either SBRT or lobectomy, and (ii) patients aged ≥75 years with COPD who undergo SBRT or best supportive care (BSC). Parameters for recurrence rates and Markov state utilities for appropriate AJCC stages of NSCLC were extracted from the literature and adapted to monthly time intervals. For operable patients, age- and sex-specific rates of death from all other causes were extracted from standard life tables and varied according to smoking habit. Surgical outcomes from the model were compared to Adjuvant! Online (AO). Elderly COPD patients were stratified into 4 classes according to T stage and COPD GOLD score. We report various treatment strategy overall and quality adjusted survival stratified by age, sex, smoking history, COPD, and T-stage...
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