Abstract
Synthetic Biology Research Centre (SBRC)-Nottingham (www.sbrc-nottingham.ac.uk) was one of the first three U.K. university-based SBRCs to be funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Engineering and Physical Sciences Research Council (EPSRC) as part of the recommendations made in the U.K.'s Synthetic Biology Roadmap. It was established in 2014 and builds on the pioneering work of the Clostridia Research Group (CRG) who have previously developed a range of gene tools for the modification of clostridial genomes. The SBRC is primarily focussed on the conversion of single carbon waste gases into platform chemicals with a particular emphasis on the use of the aerobic chassis Cupriavidus necator.
Highlights
The majority of this work has focussed on clostridia but the establishment of the Synthetic Biology Research Centres (SBRCs)-Nottingham has opened up the opportunity to a broader spectrum of bacteria and to include aerobes, Cupriavidus necator
Clostridia Research Group (CRG) Roadmap Technologies The CRG have developed a series of technologies which when sequentially applied, have allowed the modification of new clostridial hosts
Electricity powered the electrochemical reduction of CO2 at a cathode to produce formate, which was converted to isobutanol and 3-methyl-1-butanol by an engineered C. necator strain. With such a capacity to synthesise and store fixed carbon from CO2, C. necator offers the promise of a chassis which through synthetic biology approaches will be able to synthesise and store other, industrially important platform chemicals
Summary
Background to the CRGEstablished in 2004, the CRG conducts research on biofuels [10,11,12,13], C. difficile infection and control [14,15,16,17], understanding the food pathogen C. botulinum [18,19,20,21] as well as developing therapeutic strategies for treating solid tumours [22,23,24,25]. The majority of this work has focussed on clostridia but the establishment of the SBRC-Nottingham has opened up the opportunity to a broader spectrum of bacteria and to include aerobes, Cupriavidus necator. SBRC Focus Unlike many of the other UK SBRC’s the scope of the SBRC-Nottingham is highly directed and focuses on the conversion of waste C1 gases through bacterial fermentation to industrially useful hydrocarbon-based chemicals.
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