Abstract

AbstractThe annotation of Systems Biology Markup Language (SBML) models with semantic terms has been supported for a number of years. The prevalence of such annotated models is growing, with repositories such as Biomodels.net and an increasing number of software tools supporting and encouraging their use and development.With the increasing use of semantic annotations in the context of systems biology modeling has come the realization that the current Core SBML specification defining their use contains limitations that reduce the scope of metadata that can be captured in such models.SBML Level 3 provides the facility to propose and develop optional extensions to the Core specification. One such extension is described here, with an initial proposal of an Annotation package.This proposal extends the current Core annotation specification to provide support for a richer set of semantic annotations while adhering more closely to the existing specification of Resource Description Framework (RDF).

Highlights

  • Introduction and motivationAnnotations encode meta-information in SBML models

  • The Resource Description Framework (RDF) Primer generalises the concept of a “web resource” to represent information about things that can be identified on the web, even when they cannot be directly retrieved on the web

  • The basic concept of RDF is the identification of things using Uniform Resource Identifiers (URIs)

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Summary

Version information

Version number and date of public release This is version 1 of the Annotation package proposal. It reflects the results of the Annotation package meeting, 19–21 May 2010. URL or this version of the proposal Annot package proposal version 1 (2011-02). URL for the previous version of this proposal None

Introduction and motivation
Introduction to RDF
RDF Statements
RDF notations
SBML Core annotation standard
Statements about attributes
Statements about statements
Relations between statements
Predicates and qualifiers
The Annot Package proposal
Prototype implementations

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