Abstract
Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL-1).
Highlights
Mesoporous silicas discovered in the early 1990s have found numerous applications in science and industry because of their versatility, high surface area, thermal resistance and ease of surface functionalization
Melting point of acetylated gallic acid was found at 168–171°C, which is in agreement with literature data [27]
IR characterization of acetylated gallic acid confirmed the presence of essential moieties
Summary
Mesoporous silicas discovered in the early 1990s have found numerous applications in science and industry because of their versatility, high surface area, thermal resistance and ease of surface functionalization. The use of SBA-15 mesoporous silica in the preparation of controlled drug release systems is well known [10] and anticancer drugs, besides the anti-inflammatory drugs, have been most intensively delivered in such systems. Most of these systems rely on the adsorption properties of anticancer drugs and gate-like structures located at the pore entrances [11] or on surface modifications [12] affecting the adsorption process. Bound drugs require endocytosis of the silica particles by the tumor cells as already been reported in literature[14]. The addition of covalently conjugated folic acid enhances the particles uptake[14,15]
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