Abstract
An application of natural antioxidants remains the focus of research groups. The effect of Satureja montana L. essential oil in various doses on the main biological characteristics of Wistar rats was the main aim of the study. The intensification of protein metabolism in the blood plasma of rats on the background of the use of Satureja montana L. essential oil was noted. Total protein increases by 17.9 – 19.7%, and albumin by 27.6% in rats of the experimental group received the essential oil at a dose of 0.6 ml per kg of feed. A significant increase in the AST level in control group rats to 207.3 U.L-1 was revealed. Its one to a certain extent indicates the hepatoprotective effect of mountain savory oil and a decrease in inflammatory processes in the organs of the gastrointestinal tract in the conditions of cell maintenance of rats of the experimental groups. Gastric epithelium thickness of rats of both experimental groups was lower than the control animals. But it did not bear any signs of atrophy. The difference of this indicator in comparison with control was 12.75 μm (p ≤0.05) in the second group and it was reliable. The number of chief stomach cells increases in animals of the experimental groups, which may indicate a greater enzymatic activity. An increased dose of mountain savory oil contributes to the formation of more damage to hepatocytes on the periphery of the liver lobule. Thus, the relationship between liver enzymes and the state of peripheral hepatocytes was noted.
Highlights
The interest in natural-origin antioxidants due to the significant content of biologically active substances increased in recent years all over the world
An increased dose of mountain savory oil contributes to the formation of more damage to hepatocytes on the periphery of the liver lobule
The body weight increasing in both experimental groups of rats mountain savory essential oil using contributed
Summary
The interest in natural-origin antioxidants due to the significant content of biologically active substances increased in recent years all over the world. The study of the effect of natural antioxidants on rats is widely practiced because of a simple and understandable model for research (Nurmawati et al, 2021; Widyastuti et al, 2020; Fauza et al, 2019). Essential oils (EO) are one of these antioxidants. EO has antiseptic, antibacterial, antiparasitic, antifungal, insecticidal, anti-inflammatory, and regenerating properties. It exerts a defined effect on the body, regardless of the different ways of application. The effect is usually intensified with prolonged use (Krishan and Narang, 2014)
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