Abstract

Steady state Cl − flux across the Ehrlich mouse ascites cell membrane was studied when gluconate replaced Cl − in the external medium. Saturation behavior was observed; K 1 2 was 23.9 mM Cl − and V was 758 μmol · g −1 dry weight · h −1. The cells lost K +, Cl − and H 2O, consistent with relative impermeability to gluconate, and the Cl − efflux rate coefficient was elevated. The results indicate that a major portion of Cl − exchange occurs as a membrane transport process and suggest that the process is sensitive to intracellular Cl − levels.

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