Abstract
Sarcomatoid carcinoma is a rare and aggressive variant of squamous cell carcinoma. This lesion is unique in that it presents as a biphasic tumor characterized by a dysplastic epithelial component with a stromal element with invasive spindle cells, which acquires a mesenchymal phenotype. This malignancy accounts for 3% of all head and neck squamous carcinomas and for less than 1% of oral cavity tumors with just a few cases reported in the literature.1 Sarcomatoid carcinoma may be difficult to discern from osteosarcoma as the epithelial cells in the sarcomatous metaplasia may not retain any identifiable markers via immunohistochemical staining and may start to express aberrant mesenchymal markers leading to a false sarcoma diagnosis.
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