SAT405 Bone Analysis Of Transgender Women Amateur Athletes Undergoing Gender-affirming Hormone Therapy

Abstract

Abstract Disclosure: L.D. Santos: None. F.P. Nakamoto: None. R.E. Ferreira: None. R.C. Barbosa: None. L.H. Falcão: None. C.P. Cruz: None. G.B. Achkar: None. B.M. Sá: None. F.M. Lima: None. L.A. Alvares: None. Introduction: At the end of puberty, cisgender men (CM) have stronger bones and muscle mass than cisgender women (CW). Studies have shown a high prevalence of low bone mass in the general population of (transgender womenan) (TW). However, few articles are concerned with lean mass and bone mass in TW athletes. Objective: To assess the bone density of amateur volleyball TW athletes and compare them with CM and CW. Methods: A cross-sectional study was carried out with 8 TW (29 yo, range 27-36); BMI 24.1, range 19.3-31.7), 11 cisgender women (CW) and 8 cisgender men (CM) matched by age and BMI. The height (cm) of TW was 172 (range 164-181), that of CW was 176±0.1 and that of CM was 185±5.6. The TW had received hormone therapy for 3 (range 1-16) years. Measurements of BMD and body composition were taken with dual-energy X-ray absorptiometry. Results: The LS-BMD (lumbar spine) (g/cm2) of TW was 1.283 (range 0.9770-1.498), that of CW was 1.529±0.1614, and that of CM was 1.5115±0.1883 (TW vs. CW, p>0.05; TW vs. CM, p>0.05; CW vs. CM p>0.05). The FN-BMD (femur neck) (g/cm2) of TW was 1.203 (range 0.9660-1.332), that of CW was 1.337±0.1629, and that of CM was 1.4448±0.1334 (TW vs. CW, p>0.05; TW vs. CM, p<0.05; CW vs. CM p>0.05). Android/gynecoid (AG) ratio: TW: 0.85 (range 0.47-1.4); CW 0.73±0.13, CM 1.10±0.24. The lean corporal mass (kg) was 54.4 (range 44.3-66.9) in TW, 51.9±8.1 in CW, and 67.5±6.3 in CM (TW vs. CW, p>0.05; TW vs. CM, p<0.05; CW vs. CM p<0.05). Discussion: We observed lower bone density in TW amateur athletes undergoing gender-affirming hormone therapy, as well as in the general TW population. Despite the lack of statistical significance, probably as a consequence of the number of volunteers, the AG ratio was intermediate in TW. Lean mass was equal between TW and CW, unlike in the general TW population in other cohorts thay analyzed non-athelets. Conclusion: Despite their high volume of physical activity, there was a lower BMD in the TW group than in the other groups. Presentation: Saturday, June 17, 2023