SAT-266 EVALUATION OF AORTIC CALCIFICATION VOLUME AND SITES USING A NEWLY DEVELOPED THREE-DIMENSIONAL VISUALIZATION AND QUANTIFICATION METHOD IN CHRONIC KIDNEY DISEASE PATIENTS WITH AND WITHOUT DIABETES

Abstract

Chronic kidney disease (CKD) and diabetes mellitus (DM) are both crucial risk factors for vascular calcification, CVD and mortality. There are a great number of studies regarding the severity of vascular calcification in CKD and DM. While Agatston scoring is often used evaluating coronary artery calcification, there are very few studies to evaluate both severity and site of aortic calcification. The purpose of our study was to examine the volume and site of aortic calcification in CKD patients with and without DM using a newly developed three-dimensional visualization and quantification method. Fifty patients who were hospitalized and started hemodialysis at our hospital were included in the present study. They were divided into the two groups depending on the presence of DM; those with CKD and without DM group (CKD group, n=31), those with CKD and DM group (CKD+DM group, n=19). The volume and site of aortic calcification were assessed by CT-scan using a three-dimensional visualization and quantification method according to a previous study (Figure). We compared the calcification volume in total aorta and each of the five sites between the two groups. Total calcification volume was significantly greater in the CKD+DM group than in the CKD group. As for calcification sites, calcification volume in the thoracic aorta and abdominal aorta was greater in CKD+DM group compared to the CKD group. There were no significant differences in calcification volume in the aortic root, ascending aorta, and aortic arch. Total calcification volume of the aorta, calcification volume of the thoracic aorta, and calcification volume of the abdominal aorta were each significantly correlated with age, diastolic blood pressure and pulse pressure. Using a newly developed three-dimensional visualization and quantification method, the present study demonstrated that aortic calcification was more severe in CKD patients with DM than in those without DM and that calcification seemed to be likely to occur especially in the abdominal aorta. To clarify the mechanisms, a future detailed study is needed.