SAT-246 Insulin-Like Growth Factor-1 and Binding Protein-3 in Children with Metabolic Syndrome

Abstract

Purpose: To examine the association of insulin-like growth factor-1 (IGF-1) and binding protein-3 (IGFBP-3) with metabolic parameters of childhood obesity and assess their relationship with the prevalence of metabolic syndrome (MetS) in childrenMethods: This was a cross-sectional study of a total 307 children who are subcategorized into three groups according to body mass index (BMI) percentile for age and gender. (Subjects included 207 normoweight, 36 overweight, and 64 obese children). Auxological profiles and biochemical data including metabolic parameters associated with obesity, basal glycemia and insulin resistance were collected. Serum IGF-1 and IGFBP-3 levels were measured along with their standard deviation score (SDS). Results: Eleven subjects satisfied MetS criteria out of 98 children who were 10 years old or older. BMI was not significantly different in children with different quartile levels of IGF-1 SDS, IGFBP-3 SDS and IGF-1 to IGFBP-3 ratio. Alanine aminotransferase, uric acid and total cholesterol were inversely associated with IGF-1 SDS while not related to IGFBP-3 SDS or IGF-1 to IGFBP-3 ratio. IGF-1 SDS was lower in children with MetS compared to ones without MetS), however showed no difference among three groups subdivided with reference to BMI. Low IGF-1 SDS and high IGFBP-3 SDS were found to be risk factors for MetS. In children with MetS, no significant associations existed between IGF-1 SDS, IGFBP-3 SDS, or IGF-1 to IGFBP-3 ratio and the single components of MetS. Conclusion: Low IGF-1 may be a suggested risk factor of both childhood obesity and the presence of metabolic syndrome of youth. The elucidation of the role of IGFs might help to understand their metabolic actions in obesity related condition.