SAT-095 CLINICAL OUTCOME OF KIDNEY TRANSPLANTATION FROM DECEASED DONORS WITH ACUTE KIDNEY INJURY

Abstract

There are reports that kidney transplantation (KT) from donors with acute kidney injury (AKI) have similar long-term renal function and graft survival compared with KT from donors without AKI, but there is no established recommendation. Clinicians may hesitate to use the kidney with acute kidney injury due to fear of a poor outcome. This study aimed to investigate the clinical outcome in patients who received kidneys from deceased donors with AKI. From 1998 to 2016, we retrospectively reviewed patients undergone kidney transplantation from deceased donors. We divided donors into two groups of AKI (acute kidney injury) group and non-AKI group. We analyzed delayed graft function, serum creatinine at 1-month after KT, serum creatinine at 1-year after KT, cold ischemic time, donor’s initial and last serum creatinine level, The Kidney Donor Profile Index (KDPI) etc. Of 181 recipients, kidneys from 21 donors with AKI were transplanted into 30 recipients (AKI group). Another 151 recipients received kidneys from donors without AKI (Non-AKI group). Delayed graft function developed more frequently in the AKI group than in the non-AKI group (40% vs 7.28%; P <0.001). Allograft functions at 1-month and 1-year after KT did not differ between the AKI and non-AKI groups(1-month sCr : 1.25 vs 1.30, p=0.469, 1-year sCr: 1.38 vs 1.13, p=0.691). KT from deceased donors with AKI showed comparable outcomes at 1,6 and 12 months despite high rates of delayed graft function. Our clinical outcome suggests that kidneys from donors with AKI are a potential source to expand the donor pool.