SAT0562 BURDEN OF RHEUMATIC DISEASE AMONG KOREAN WOMEN IN CHILDBEARING YEARS BASED ON THE NATIONAL HEALTH INSURANCE SERVICE

Abstract

Background: Many rheumatic diseases (RDs) predominantly affect women in their reproductive years, and have a significant impact on childbearing, but its burden remains incompletely understood. Objectives: The study aimed to identify the prevalence and incidence of RDs among Korean women in childbearing years, and the effect of the diseases on prevalence of comorbidities, medication use, and pregnancy rate. Methods: From National Health Insurance Service data during 2009-2016, we identified 9,217,139 women aged between 20-44 years. Among these women, we estimated the prevalence and incidence of RDs including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). Prevalence of chronic diseases such as cancer (Ca), hypertension (HT), hyperlipidemia (HLD), and diabetes mellitus (DM) was compared in women with or without RDs. The prescription prevalence of medications including NSAIDs and corticosteroids were compared according to the presence of RDs. We also investigated pregnancy rate in women with rheumatic or chronic diseases, and control subjects without rheumatic or chronic diseases. Results: Overall prevalence of RDs was 56.3 per 100,000 20-44 aged females, and overall incidence was 7.68 cases per 100,000 person-years. Women with RDs had increased risk for overall chronic diseases (OR 3.0), and for Ca (OR 1.3), HT (OR 1.4), HLD (OR 2.9), and DM (OR 2.8), respectively (p Conclusion: RDs are a significant burden for women in childbearing years causing increased co-morbidities and medication use and causing reduced pregnancy rate.