SAT0231 AGE AND THE CLINICAL FEATURES OF ADULT IGA VASCULITIS

Abstract

Background IgA vasculitis (IgAV) is a common vasculitis of adult population, yet the disease in adults is still poorly defined. Objectives The aim of our study was to evaluate the potential influence of age on the presentation of adult IgAV. Methods We analyzed medical records of adult, histologically proven IgAV cases, diagnosed and followed at our secondary/tertiary rheumatology center between January 2010 and December 2018. We stratified IgAV cases into four groups, based on the patient age at presentation (18-39, 40-59, 60-79 and ≥80 years). The clinical features were compared between the groups. Results During the 108-month observation period we identified 265 new IgAV cases (60.0% males, median (IQR) age 64 (45–77) years). Skin, joint, gastrointestinal tract (GIT) and renal involvement developed in 265, 103 (38.9%), 80 (30.2%), and 118 (44.5%) cases, respectively. Younger adults (≤40 years) more frequently reported an infection prior to IgAV, and developed arthritis or GIT involvement. Severe renal involvement was less common under the age of 40 years. The incidence of skin limited IgAV and of necrotic purpura increased with patient age. Follow-up data were available for 189 patients. During a median (IQR) follow-up of 12 (6–24) months, 29 (15.3%) patients relapsed. Relapsing disease was more frequent in younger adults (≤40 years), compared to older ones. Data on age related variations in the clinical presentation of IgAV are presented in Table 1. Conclusion We found subtle age related differences in the presentation and during follow up of adult IgAV. Disclosure of Interests None declared