SAT0173 Does osteoarthritis decrease the risk of osteoporosis ? a prospective clinical study

Abstract

Background Osteoporosis (OP) and Osteoarthritis (OA) are the most prevalent musculuskeletal diseases of the population. The inverse relationship between the OP and OA is being investigated in the last four decades. After the invention of the non-invasive techniques for the measurement of bone mineral density, this relationship was studied more detailed. Objectives This study was planned to investigate the relationship between OA and OP, to find out the OP rate in the subgroups of the OA and to help for the diagnosis, treatment and prevention of the OP. Methods Forty-six female patients, who had an OA diagnosis according to the ACR criteria were admitted to the study. Twelve of them had knee OA, 12 had lumbar OA, 12 had hand OA and 10 had both lumbar and knee OA. In the control group there were 26 healthy women in similar ages. Patients who had the diseases that cause to the secondary OP like RA, gout, DM, thyroid and parathyroid function disorders and who used the drugs that is known to effect the bone metabolism like corticosteroids, antiepileptics and thiazid diuretics, were excluded from the study. Bone mineral density measurement was made from L2-L4 vertebra and femur neck with DEXA anteroposterior projection. The DEXA results of the OA subgroups were compared with the healthy controls and the relationship between them was evaluated. Results Although bone mineral density scores of knee and lumbar OA group were both higher than control group, only lumbar vertebra group was statistically significant. There wasn’t a significant difference between the hand and control group bone mineral density results. The results suggest that the lumbar and knee OA have a positive effect on the bone mineral density and the femur is effected less than the lumbar vertebra which is seemed to be the target area of this relationship. No correlation was found in the hand OA group. Conclusion We think that the increased bone mineral density at the knee and lumbar OA group can be a negative indicator for the prevention and treatment of OP but in our opinion the hand osteoarthritis group is not a good negative indicator.