SAT-286 ULTRAFILTRATION FAILURE IN PERITONEAL DIALYSIS: PREVALENCE AND RISK FACTORS

Abstract

Ultrafiltration Failure (UFF) is a common problem in peritoneal dialysis (PD) secondary to changes in peritoneum structure and functions. It’s occurrence limits the use of DP in the long term. The prevalence of UFF varies between 5.4% and 36% depending on the team. The objective of this work is to determine the prevalence of UFF as well as the potential risk factors involved. this is a retrospective descriptive study conducted in the nephrology department in Monastir from 1990 to December 2017. The demographic and clinico-biological characteristics of the patients were collected. We divided our patients into 2 groups: Group 1 with UFF and Group 2 unscathed. 304 patients with male predominance were included. The average age was 46.47 ± 18.6 years. The median duration of dialysis was 68 months (95%, CI [47, 90]). UFF was observed in 60 patients, a prevalence of 19.7%. It was the main cause of hemodialysis transfer (42% of cases). The mean age of group 1 was 42.4 ± 16 years with a sex ratio H / F 2.53. The statistical study found no significant correlation between the UFF and multiple factors (sex, age, hypertension, heart failure and technical modality). On the other hand, a significant correlation was found with diabetes (p = 0.02) and the occurrence of peritonitis (p <0.01). Hyper-permeable membranes (H), classic cause of UFF, were more common among Group 1. The mean survival time of group 1 was 41.4 ± 26 months. Ultrafiltration failure seems to be frequent in our cohort. Peritonitis and diabetes status are contributing factors. The impactful therapeutic option remains the prevention of this complication.